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24 Ιουν 2024 · HIV 3D Structure Viewer. Purpose: To view 3D structures of HIV proteins and to map a desired sequence (e.g., short functional domain or epitope) directly onto the interactive graphic. Usage: Choose a structure or upload a structure file in PDB format. Uploading a sequence is not required; any sequences provided will be aligned with the structure sequence and displayed.
1 Νοε 1996 · Improved cyclic urea inhibitors of the HIV-1 protease: synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450.
HIV-1 protease or PR is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential for the life-cycle of HIV, the retrovirus that causes AIDS.
Antiviral inhibitors of HIV-1 protease are a notable success of structure-based drug design and have dramatically improved AIDS therapy. Analysis of the structures and activities of drug resistant protease variants has revealed novel molecular ...
Structures of all four of these drugs bound to HIV-1 protease are available at the PDB. In the illustration, the enzyme is displayed as a ribbon that follows the two protein chains and the drugs are shown as spacefilling models.
23 Νοε 2024 · In this chapter, we present a comprehensive review of the structural and functional studies on HIV protease, including its significance in the AIDS treatment, its catalytic mechanism, subtypes, inhibitors, and the evolution of drug resistance to protease inhibitors.
HIV-1 protease structure. (A) Ribbon diagram of HIV-1PR showing various structural elements as described by Wlodawer (Wlodawer & Gustchina, 2000). (B) Overlay of HIV-1PR conformations showing how regions of the protein move during opening and closing of the β-hairpin “flaps.” (C) Ribbon diagram showing ball and stick representations of ...
