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Antiviral inhibitors of HIV-1 protease are a notable success of structure-based drug design and have dramatically improved AIDS therapy. Analysis of the structures and activities of drug resistant protease variants has revealed novel molecular ...
1 Οκτ 2009 · Antiviral inhibitors of HIV-1 protease are a notable success of structure-based drug design and have dramatically improved AIDS therapy. Analysis of the structures and activities of drug resistant protease variants has revealed novel molecular mechanisms of drug resistance and guided the design of tight-binding inhibitors for resistant variants.
23 Νοε 2024 · In this chapter, we present a comprehensive review of the structural and functional studies on HIV protease, including its significance in the AIDS treatment, its catalytic mechanism, subtypes, inhibitors, and the evolution of drug resistance to protease inhibitors.
24 Ιουν 2024 · HIV 3D Structure Viewer. Purpose: To view 3D structures of HIV proteins and to map a desired sequence (e.g., short functional domain or epitope) directly onto the interactive graphic. Usage: Choose a structure or upload a structure file in PDB format. Uploading a sequence is not required; any sequences provided will be aligned with the structure sequence and displayed.
Structure of HIV Protease. HIV protease begins as a component of the Gag/Pol fusion polyprotein. As a single molecule, the Gag/Pol-embedded protease is inactive, because dimer formation is required to create the active site and catalytic machinery.
HIV protease, the third virally encoded enzyme, is required in this step to cleave a viral polyprotein precursor into individual mature proteins. The viral RNA and viral proteins assemble at the cell surface into new virions, which then bud from the cell and are released to infect another cell.
1 Ιαν 2021 · Viral proteases are diverse in structure, oligomeric state, catalytic mechanism, and substrate specificity. This chapter focuses on proteases from viruses that are relevant to human health: human immunodeficiency virus subtype 1 (HIV-1), hepatitis C (HCV), human T-cell leukemia virus type 1 (HTLV-1), flaviviruses, enteroviruses, and coronaviruses.
