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Folic acid and/or folinic acid supplementation in autism spectrum disorder diagnosed children has led to improvements, both in some neurologic and behavioral symptoms and in the concentration of one-carbon metabolites.
- Is High Folic Acid Intake a Risk Factor for Autism?—A Review
Abstract. Folate is required for metabolic processes and...
- Does high-dose gestational folic acid increase the risk for autism? The ...
There has been a dramatic increase in the incidence of...
- The Relationship between Folic Acid and Risk of Autism Spectrum ...
The mean (±SEM) folic acid intake was significantly greater...
- Folic acid and autism: updated evidences - PubMed
The evidence of insufficient folic acid intake in most...
- Folic Acid and Autism: A Systematic Review of the Current ... - PubMed
Studies have pointed out a potential beneficial effect of...
- Is High Folic Acid Intake a Risk Factor for Autism?—A Review
Abstract. Folate is required for metabolic processes and neural development. Insuring its adequate levels for pregnant women through supplementation of grain-based foods with synthetic folic acid (FA) in order to prevent neural tube defects has been an ongoing public health initiative.
There has been a dramatic increase in the incidence of autism spectrum disorder (ASD) in recent decades but the causes have not been elucidated. To date, numerous studies have shown that the FDA-recommended doses of folic acid (400 mcg/d) render a protective effect against ASD.
Folic acid supplementation during early pregnancy was associated with a lower risk of offspring’s ASD [OR 0.57, 95% CI 0.41–0.78]. The consumption of a daily amount of at least 400 μg folic acid from dietary sources and supplements, was associated with a reduced risk of offspring ASD [OR 0.55, 95% CI 0.36–0.83].
23 Οκτ 2014 · The mean (±SEM) folic acid intake was significantly greater for typical development children than for mothers of children with ASD (p < 0.01) in first month of pregnancy. A mean folic acid intake of ≥ 600 µg vs. <600 µg was associated with reduced risk of ASD (AOR = 0.62, 95% C.I. = 0.42–0.92)
The evidence of insufficient folic acid intake in most individuals with ASD remains consistent in this update. No association was found between maternal exposure to folic acid and the risk of ASD in their children.
3 Αυγ 2021 · Studies have pointed out a potential beneficial effect of prenatal folic acid maternal supplementation (600 µg) on the risk of autism spectrum disorder onset, but opposite results have been reported as well.
