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Transmission refers to the relay functions by which the message is carried from the site of tissue injury to the brain regions underlying perception. Modulation is a recently discovered neural process that acts specifically to reduce activity in the transmission system.
24 Ιουλ 2023 · Nociceptive signal transduction to the brain is what elicits the perception of pain. The complex biopsychosocial phenomenon of pain occurs in the cortical and subcortical regions, such as the thalamus, amygdala, hypothalamus, periaqueductal grey, basal ganglia and areas of the cerebral cortex.
1 Νοε 2021 · Pain can be anatomically and phenomenologically dissected into three separable but interacting pathways, a lateral ‘painfulness’ pathway, a medial ‘suffering’ pathway and a descending pain inhibitory pathway. In chronic pain the descending pain inhibitory pathway is less activated.
Abstract. Pain is an integrative phenomenon that results from dynamic interactions between sensory and contextual (i.e., cognitive, emotional, and motivational) processes. In the brain the experience of pain is associated with neuronal oscillations and synchrony at different frequencies. However, an overarching framework for the significance of ...
28 Σεπ 2015 · This article describes how that “pain message” is transmitted to the spinal cord and the brain and how the brain responds to the stimulus, while identifying pain relief strategies linked to the physiological process.
Pain involves a complex interplay between messages sent from the periphery to the central nervous system and vice versa. Specific pathways play a vital role in carrying these messages, and modulating, or exacerbating their downstream effects.
10 Νοε 2021 · These neurons, in turn, project to the lateral parabrachial nucleus (lPB) and the periaqueductal gray (PAG), which then connect with the anterior cingulate, insular, and prefrontal cortices, medial thalamus, amygdala, nucleus accumbens, and hypothalamus to generate and modulate pain experience.
