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24 Ιουλ 2023 · Nociceptive signal transduction to the brain is what elicits the perception of pain. The complex biopsychosocial phenomenon of pain occurs in the cortical and subcortical regions, such as the thalamus, amygdala, hypothalamus, periaqueductal grey, basal ganglia and areas of the cerebral cortex.
Pain is a subjective experience with two complementary aspects: one is a localized sensation in a particular body part; the other is an unpleasant quality of varying severity commonly associated with behaviors directed at relieving or terminating the experience.
1 Νοε 2021 · Pain can be anatomically and phenomenologically dissected into three separable but interacting pathways, a lateral ‘painfulness’ pathway, a medial ‘suffering’ pathway and a descending pain inhibitory pathway. In chronic pain the descending pain inhibitory pathway is less activated.
Abstract. Pain is an integrative phenomenon that results from dynamic interactions between sensory and contextual (i.e., cognitive, emotional, and motivational) processes. In the brain the experience of pain is associated with neuronal oscillations and synchrony at different frequencies. However, an overarching framework for the significance of ...
1 Αυγ 2022 · They found that pressure pain (acute pain) increased brain activity in most of the same brain regions in both groups (e.g., insula, ACC, PFC) while spontaneous pain evoked activity in the PFC and limbic regions (medial PFC, orbitofrontal cortex, accumbens, and amygdala).
Pain involves a complex interplay between messages sent from the periphery to the central nervous system and vice versa. Specific pathways play a vital role in carrying these messages, and modulating, or exacerbating their downstream effects. This review describes the anatomy and physiology of pain emphasizing targeted treatment pathways of pain.
Painful stimuli are transduced by nociceptors into electrical and chemical signals, and transmitted from the periphery to the central nervous system, in a pathway called the ascending pain pathway or spinothalamic tract.
