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  1. Because heightened physical pain sensitivity is a commonly induced by inflammation we examined whether inflammatory mechanisms could also increase social pain sensitivity, as indexed by a heightened sense of social disconnection and greater neural sensitivity to social exclusion.

  2. 2 Αυγ 2016 · Here, we review research showing: (1) that exposure to social stressors increases proinflammatory activity, (2) that individuals who are more socially isolated (ie, lonely) show increased...

  3. 18 Μαΐ 2020 · It seems that increased or decreased social pain could alter physical pain in a parallel manner, meaning that social pain might lead an individual to feel increased physical pain. These shared functional brain regions provide evidence for the interaction between social and physical pain.

  4. 10 Ιουν 2015 · Several studies have isolated the neural regions associated with social and physical pain and we had specific hypotheses that the affective pain system and DMPFC would be associated with social pain reliving, while the sensory pain system and IFG would be associated with physical pain reliving.

  5. 1 Νοε 2021 · The genetic and epigenetic factors modulate neuroinflammation, which is involved in peripheral and central sensitization. Chronic pain, with a prevalence of 20–30 % is the major cause of human suffering worldwide. Perceived pain disability correlates highly with suffering, little with painfulness.

  6. This review summarizes findings in this field, specifically highlighting work that provides support for the idea that inflammation can lead to 1) increases in sensitivity to negative, threatening social experiences and 2) increases in sensitivity to positive, socially rewarding experiences.

  7. 3 Μαΐ 2012 · Neuroimaging research has demonstrated that experiences of social exclusion predominantly activate the dorsal anterior cingulate cortex (dACC) and anterior insula (AI) — regions known to have a...