Αποτελέσματα Αναζήτησης
21 Μαΐ 2024 · We will review the genetic mechanisms underlying major childhood cancers and outline recent preclinical and clinical advances in gene therapy for various malignancies. We will also examine key challenges such as delivery barriers, safety concerns, manufacturing issues, and potential solutions.
- The Current Status of Gene Therapy for the Treatment of Cancer
Gene Therapy for Cancer Treatment. Cancer occurs due to...
- The Current Status of Gene Therapy for the Treatment of Cancer
2 Ιουλ 2024 · Clinical whole-genome sequencing (WGS) has been shown to deliver potential benefits to children with cancer and to alter treatment in high-risk patient groups.
27 Φεβ 2024 · With the introduction of germline genetic sequencing for all pediatric cancer patients, regardless of their anticipated risk of having a cancer predisposition, there is a need for more...
6 Μαρ 2019 · Childhood cancers are developmentally distinct from adult cancers and arise from cellular reprogramming as a result of epigenetic mutations or gene fusions, providing unique therapeutic...
6 Ιουν 2014 · Emerging applications of gene therapy now include skin and neurological disorders such as epidermolysis bullosa, epilepsy and leukodystrophy. Gene therapy trials for haemophilia, muscular dystrophy and a range of metabolic disorders are underway.
1 Απρ 2021 · Two of the most successful molecularly targeted therapies for children with solid tumors to date have been larotrectinib and entrectinib, which inhibit TRKA, TRKB, and TRKC in neurotrophic tyrosine receptor kinase (NTRK) fusion-positive malignancies. 153, 154 NTRK fusions occur across a wide range of cancers but, in children, have been ...
Gene Therapy for Cancer Treatment. Cancer occurs due to disrupting the normal cell proliferation and apoptosis process. Advances in cancer therapy need a novel therapeutic agent with novel mode of action, several mechanisms of cell death, and synergy with conventional management.
