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The aim of this review is to determine if there are any clinically relevant differences in safety between ibuprofen and paracetamol that may recommend one agent over the other in the management of fever and discomfort in children older than 3 months of age. Keywords: Acetaminophen; Children; Ibuprofen; Paracetamol; Safety. Publication types. Review
Ibuprofen is the most widely used non-steroidal anti-inflammatory drug (NSAID) for the treatment of inflammation, mild-to-moderate pain and fever in children, and is the only NSAID approved for use in children aged ≥3 months.
Based on the current evidence, short-term use of ibuprofen is considered safe in infants older than 3 months of age having a body weight above 5-6 kg when special attention is given to the hydration of the patient.
2 Σεπ 2022 · Key Points. This review summarizes the efficacy and safety of the non-steroidal anti-inflammatory drugs (NSAIDs) that are available to treat pain in infants (children < 2 years of age). Most information is available for ibuprofen, ketoprofen, and ketorolac.
2 Ιουλ 2021 · Ibuprofen can provide a better pain relief with fewer adverse effects in children with musculoskeletal injuries as compared to other analgesics. This meta-analysis supports ibuprofen as the first-line drug for children with musculoskeletal injuries.
6 Ιαν 2017 · In a randomized controlled trial in febrile asthmatic children, those who received ibuprofen were less likely to be hospitalized and significantly less likely to require outpatient visits for asthma compared with children who received paracetamol (Lesko et al. 2002).
26 Αυγ 2024 · We performed a retrospective analysis of the National Poison Data System for acetaminophen and ibuprofen single-substance exposures in teenagers 13–19 years of age from 2017–2022. Acetaminophen and ibuprofen overdoses (per 100,000 persons) were plotted by year.
