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1. en.wikipedia.org › wiki › Immunoglobulin_DImmunoglobulin D - Wikipedia

   en.wikipedia.org › wiki › Immunoglobulin_D

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   Immunoglobulin D (IgD) is an antibody isotype that makes up about 1% of proteins in the plasma membranes of immature B-lymphocytes where it is usually co-expressed with another cell surface antibody called IgM.

2. microbiologyinfo.com › immunoglobulin-d-igdImmunoglobulin D (IgD) – Properties, Structure and Functions

   microbiologyinfo.com › immunoglobulin-d-igd

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   23 Ιαν 2024 · IgD is a unique immunoglobulin that acts as an antigen receptor on B cells and may regulate B cell maturation and activation. It has a long hinge region that allows it to bind to antigens with widely spaced epitopes and enhance humoral immune responses.

3. pubmed.ncbi.nlm.nih.gov › 29733429The enigmatic function of IgD: some answers at last - PubMed

   pubmed.ncbi.nlm.nih.gov › 29733429

   The enigma of dual IgD and IgM expression has been tackled by several recent studies showing that IgD helps peripheral accumulation of physiologically autoreactive B cells through its functional unresponsiveness to self-antigens but prompt readiness against foreign antigens.

4. onlinelibrary.wiley.com › doi › 10The enigmatic function of IgD: some answers at last

   onlinelibrary.wiley.com › doi › 10

   7 Μαΐ 2018 · Secreted IgD appears to enhance mucosal homeostasis and immune surveillance by “arming” myeloid effector cells such as basophils and mast cells with IgD antibodies reactive against mucosal antigens, including commensal and pathogenic microbes.

5. www.ncbi.nlm.nih.gov › pmc › articlesNew Insights into the Enigma of Immunoglobulin D - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   Immunoglobulin D (IgD) has remained an enigmatic antibody class since its discovery almost 50 years ago. Because of its spotty presence in mammals and absence in birds, IgD was initially thought to be a recently evolved Ig isotype.

6. www.sciencedirect.com › science › articleThe function and regulation of immunoglobulin D - ScienceDirect

   www.sciencedirect.com › science › article

   1 Ιουν 2011 · This study identified the cytokine signals that promote the CSR and production of human IgD, and the function of IgD in inducing immuno-activating, pro-inflammatory and antimicrobial functions of basophils. Findings also suggest that such functions are evolutionarily conserved from fish to human.

7. pubmed.ncbi.nlm.nih.gov › 21353515The function and regulation of immunoglobulin D - PubMed

   pubmed.ncbi.nlm.nih.gov › 21353515

   Although the nature of the IgD receptor remains elusive, cross-linking of IgD on basophils stimulates release of immunoactivating, proinflammatory and antimicrobial mediators. This pathway is dysregulated in autoinflammatory disorders such as hyper-IgD syndrome, indicating that IgD orchestrates an ancestral surveillance system at the interface ...