Αποτελέσματα Αναζήτησης
1 Σεπ 2022 · IgD myeloma was historically associated with worse outcomes, but we now report a standard cytogenetic risk profile and survival outcomes. Improved IgD myeloma survival is due to earlier diagnosis, improved supportive care, and response to novel antimyeloma therapies.
IgD has antibody activity to specific antigens (34, 53, 60, 109, 110); individuals with high levels of IgD can produce specific IgD antibodies after antigenic challenge .
The functions of cancer-derived Ig are distinct from those of B cell-derived Ig, which exerts antibody functions in humoral immunity. Studies have shown that cancer-derived Ig acts as a crucial protumorigenic molecule that promotes carcinogenesis via several different mechanisms.
28 Ιουν 2021 · This review will concentrate on major progress in expressions, functions, and mechanisms of tumor-derived Igs, similarities and differences between tumor-derived Igs and B-cell-derived Igs.
The enigma of dual IgD and IgM expression has been tackled by several recent studies showing that IgD helps peripheral accumulation of physiologically autoreactive B cells through its functional unresponsiveness to self-antigens but prompt readiness against foreign antigens.
7 Μαΐ 2018 · Secreted IgD appears to enhance mucosal homeostasis and immune surveillance by “arming” myeloid effector cells such as basophils and mast cells with IgD antibodies reactive against mucosal antigens, including commensal and pathogenic microbes. Here we will review these advances and discuss their implications in humoral immunity in human and mice.
Immunoglobulin D (IgD) has remained an enigmatic antibody class since its discovery almost 50 years ago. Because of its spotty presence in mammals and absence in birds, IgD was initially thought to be a recently evolved Ig isotype.
