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1 Σεπ 2022 · Key Points. IgD myeloma was historically associated with worse outcomes, but we now report a standard cytogenetic risk profile and survival outcomes. Improved IgD myeloma survival is due to earlier diagnosis, improved supportive care, and response to novel antimyeloma therapies.
Paradoxically, treatments with anti-IgD antibody suppressed and ameliorated autoimmune conditions and allergic inflammations in mouse models without compromising the host's general immune defence, demonstrating a unique and novel therapeutic application for anti-IgD antibody treatment.
Immunoglobulin D (IgD) is an antibody isotype that makes up about 1% of proteins in the plasma membranes of immature B-lymphocytes where it is usually co-expressed with another cell surface antibody called IgM.
The role of IgD (especially the secreted form) is not fully understood; it has even been thought sometime that IgD might have no function . This was investigated in animals treated with anti-IgD and, more recently, in IgD-deficient mice.
7 Μαΐ 2018 · The enigma of dual IgD and IgM expression has been tackled by several recent studies showing that IgD helps peripheral accumulation of physiologically autoreactive B cells through its functional unresponsiveness to self-antigens but prompt readiness against foreign antigens.
The presence of IgD may ensure the preservation of essential immune functions in case of IgM defects, and the structure flexibility of IgD may provide additional immune functions in a species-specific manner.
IgM antibodies primarily function to prevent binding of pathogens to cells or to aggregate pathogens, thereby enhancing physical clearance of the organism. The four subclasses of IgG antibodies are present in the highest concentration in the plasma because of their long half-lives (∼3 weeks) and high production rates.
