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IL-11 signaling pathway represents a set of reactions triggered by the binding of IL-11 to its receptor, IL11RA. Protein – protein interactions, enzyme catalysis events, and translocation...
20 Νοε 2023 · Here the authors describe structures of IL-11 in complex with its receptors and determine the molecular mechanisms through which a variant of IL-11 inhibits signalling, opening avenues...
1 Δεκ 2016 · Schematic representation of the IL-11 signaling pathway. IL-11 signaling activity begins with binding of soluble IL-11 to membrane bound IL-11Rα, followed by its engagement with GP130, dimerization of GP130, and the final formation of a hexameric complex of one GP130 homodimer plus two IL-11/IL-11Rα.
Interleukin (IL)-6 family cytokines, such as IL-6 and IL-11, are defined by the shared use of the gp130 receptor for the downstream activation of STAT3 signaling and the activation of genes...
Download scientific diagram | Intracellular IL-11 signal transduction pathways. from publication: Interleukin-11 in Pathologies of the Nervous System | The study of the role of...
1 Ιαν 2022 · IL-11 engages its cognate receptor in three ways: (A) through ‘Classic signalling’, whereby IL-11 binds to membrane-bound IL-11Rα, which then binds to membrane-bound GP130 on the same cell; (B) through ‘trans signalling’, whereby IL-11 binds to soluble IL-11Rα and then binds to membrane-bound GP130; or (C) through ‘trans ...
1 Δεκ 2020 · Here, we summarize the current and emerging roles of the cytokine interleukin (IL)-11 in the context of lung diseases and pulmonary fibrosis, with a focus on its central role in myofibroblast...
