Αποτελέσματα Αναζήτησης
11 Μαΐ 2022 · The interleukin-23 [IL-23] cytokine, derived predominantly from macrophages and dendritic cells in response to microbial stimulation, has emerged as a critical promoter of chronic intestinal inflammation.
15 Ιουν 2023 · IFN-γ may enhance hematopoietic activity at the level of primordial HSCs, which maintain the increased production of downstream and non-self-renewing GMPs. GM-CSF plays a vital role in causing GMPs to accumulate outside the bone marrow in cases of IL-23-dependent intestinal inflammation.
7 Οκτ 2023 · IL-23A [IL-23 p19 −/−] knockout (KO) mice were crossed to Apc min/+ mice and progeny were fed low-fat or high-fat diets. At termination intestines were evaluated for tumorigenesis. Tumors, serum, and fecal contents were analyzed for protein biomarkers, cytokines, and microbiome profile respectively.
We report that IL-23 transgene expression was sufficient to induce rapid (3–4 weeks) de novo development of intestinal adenomas with 100% incidence. Initiation of tumorigenesis was independent of exogenous carcinogens, Helicobacter colonization, or pre-existing tumor-suppressor gene mutations.
2 Ιουν 2023 · Targeting interleukin-23 (IL-23) has been shown to be associated with significant therapeutic benefits in clinical trials of patients with inflammatory bowel disease.
27 Νοε 2013 · Tumorigenesis was mediated by Thy1(+)IL-23R(+) innate lymphoid cells (ILC3), in part, through IL-17 responses as tumor development was inhibited in RAG(-/-) × IL-17(-/-) double knockout mice.
14 Οκτ 2021 · Interleukin-23 (IL-23) is a potential inflammatory mediator linking obesity to chronic colonic inflammation, altered gut microbiome, and colon carcinogenesis. We aimed to elucidate the role of pro-inflammatory eicosanoids and gut bacterial toxins in priming dendritic cells and macrophages for IL-23 secretion to promote colon tumor progression.
