Αποτελέσματα Αναζήτησης
16 Οκτ 2019 · For an effective novel vaccine against genital herpes the choice of antigen and adjuvant may be critical. The incorporation of adjuvants of the vaccine candidates in the past, may account for their partial efficacy.
9 Αυγ 2021 · Vaccine development for the disease caused by the herpes simplex virus (HSV) has been challenging over the years and is always in dire need of novel approaches for prevention and cure. To date, the HSV disease remains incurable and challenging to prevent.
24 Απρ 2022 · Recently, the Friedman group 18 showed that nucleoside-modified mRNA in lipid nanoparticle vaccine encoding for glycoproteins gC, gD, and gE induced strong and protective immunity against acute and latent herpes simplex virus type 2 infection in mice.
6 Δεκ 2021 · Development of the therapeutic Shingrix vaccine for Herpes Zoster and a prophylactic vaccine for varicella zoster virus (VZV) has increased efforts for HSV vaccine due to similarities between the two viruses, especially with the establishment of latency (Heineman et al., 2019).
7 Δεκ 2021 · Within this article, we will review the current guidelines for the treatment of herpes simplex infections, our understanding of the immunological pathways involved, and novel vaccine candidates in development. Keywords: DNA vaccine; herpes simplex virus type 1; herpes simplex virus type 2; live attenuated vaccine; mRNA vaccine; subunit vaccine;
We also review what is known of the natural immune control of herpes lesions, via interacting innate immunity and CD4 and CD8 T cells and the lessons they provide for development of new, more effective vaccines.
Our results of immunotherapy with GEN-003, a novel vaccine for genital herpes, composed of HSV-2 gD2ΔTMR and a fragment of ICP4 protein (ICP4.2) adjuvanted with Matrix-M2, demonstrate that it had an acceptable safety profile, was immunogenic, and reduced both recurrent viral shedding and the number of days with lesions at doses of 30 µg and ...
