Αποτελέσματα Αναζήτησης
Recently, the Friedman group 18 showed that nucleoside-modified mRNA in lipid nanoparticle vaccine encoding for glycoproteins gC, gD, and gE induced strong and protective immunity against acute and latent herpes simplex virus type 2 infection in mice.
6 Δεκ 2021 · Immunization with a vaccine combining herpes simplex virus 2 (HSV-2) glycoprotein C (gC) and gD subunits improves the protection of dorsal root ganglia in mice and reduces the frequency of recurrent vaginal shedding of HSV-2 DNA in Guinea pigs compared to immunization with gD alone.
14 Μαΐ 2019 · Prevention of HSV-2 infection would prevent associated GUD and HSV transmission, including to neonates as neonatal herpes, as well as HSV-2-associated HIV acquisition. PPCs for therapeutic HSV vaccines that reduce symptomatic HSV-2 GUD in individuals who are already infected with HSV-2.
16 Οκτ 2019 · The two great challenges in translational research for Herpes simplex virus are prevention of initial genital herpes and suppression of recurrent herpes, by prophylactic vaccines and either antivirals or immunotherapeutic vaccines respectively.
5 Αυγ 2024 · The initial GRADE evidence level was type 1 (high) for each outcome because the body of evidence was from RCTs. In terms of benefits, the available data indicated that the vaccine was effective for preventing herpes zoster, with VE ranging from 68.2% to 90.5% among several immunocompromised groups.
24 Φεβ 2022 · Herpes zoster is characterized by a painful, unilateral vesicular eruption that occurs in a restricted dermatomal distribution. Vaccines are available for prevention of both infections. This topic will address the use of the two vaccines used to prevent herpes zoster.
25 Ιουλ 2024 · HSV-2 seropositive persons with a history of symptomatic genital herpes were enrolled in a randomized, placebo-controlled study to evaluate safety and humoral and cellular immune responses in response to the vaccine.
