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When A:G ratio in dogs is low and tick/flea exposure was likely, a tick panel for systemic parasites such as Ehrlichia (e.g. Idexx#2902). In cats with low A:G ratios, bartonella PCR test (e.g. Idexx#3540) particular if associated with fevers and a history of flea exposure.
Further, the authors tested whether dogs with lower serum IgA also have low faecal IgA and/or serum IgE. To reveal whether any of the parameters could be proven to influence the immune response, the authors also measured serum IgG against canine distemper virus (CDV).
Measurement of individual immunoglobulins is performed for 2 reasons: The most commonly used test is measurement of IgG in foals, llamas and calves for failure of transfer of passive immunity. There are many different immunodeficient states that have been reported in animals.
IgG is the most common immunoglobulin in your dog's blood serum. It can recognize and neutralize various antigens or mark them for destruction by other immune cells. IgM is the first immunoglobulin produced during an infection.
When globulins are very low, this can be a sign of gastrointestinal disease, hemorrhaging, immune deficiency and certain infectious diseases. Elevated globulins on the other hand can be a sign of chronic inflammation, infection and even cancer. When the albumin is low, or the globulins are high or low, these warrant further investigation. 6.
Immune-deficiency diseases in dogs can be quite severe and pose a great deal of health issues. These diseases put the body’s defenses against any infection at high risk. Dogs with immune-deficiency disease may either have a deficiency in immunoglobulin or phagocytosis.
Primary immune-mediated hemolytic anemia (IMHA) and immune-mediated thrombocytopenia (ITP) are the most frequent forms in dogs, while secondary forms of each disease are most common in cats. In patients with IMHA, hemolysis happens either intravascularly or extravascularly.
