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The implantable bioartificial kidney builds upon the existing extracorporeal Renal Assist Device (RAD), which is a bioartificial kidney that combines a membrane hemofilter and a bioreactor of human renal tubule cells to mimic many of the metabolic, endocrine, and immunological functions of a healthy kidney.
1 Ιαν 2023 · Implantable Renal Assist Device Fissell and Roy have pursued a biomimetic hybrid approach to build an implantable renal assist device (iRAD) as a permanent solution to end-stage kidney disease. Healthy kidneys are composed of a million or more nephrons.
5 Ιουν 2023 · Portable, wearable and implantable artificial kidney systems require compact and efficient dialysate regeneration systems and novel membranes for improved toxin removal and long-term patency.
20 Απρ 2018 · The implantable renal assist device (iRAD) utilizes microelectromechanical system (MEMS) technology to scale down the original RAD design into a compact, implantable and self-sustainable BAK. The iRAD combines a long-life hemofilter made of silicon nanopore membrane (SNM) with a renal tubule cell bioreactor, such as the BRECS, with immune ...
Implantable filtration devices that address these requirements can be produced by photolithographically production of membranes made from silicon wafers, adjusting slit-shaped pores of 5–10 nm width with a precision and size distribution greatly exceeding that of conventional polymer membranes.
23 Αυγ 2018 · Developments in sorbent technology, nanotechnology, and cell culture techniques provide promise for new innovations in ESRD management. New modalities currently in testing include wearable (WAKs) and implantable artificial kidneys (IAKs). The automated WAK (AWAK) and WAK are devices that have undergone small trials in humans.
5 Ιαν 2024 · An ideal implantable device could combine bioreactors and blood ultrafiltration to replicate key native cell functions for solute reabsorption, secretion, and endocrinologic activities.
