Αποτελέσματα Αναζήτησης
Microdosing can replace certain tests on animals and help screen out drug compounds that won’t work in humans so that they are never tested in animals. Advanced brain imaging and recording techniques—such as functional magnetic resonance imaging (fMRI)—with human volunteers can be used to replace archaic experiments in which rats, cats ...
Microtissue-derived in vitro models are promising candidates to replace animal testing, as they aim to replicate small compartments of the host organ for preclinical studies, rather than focusing on the entire, highly complex organism.
27 Δεκ 2023 · Pharmaceutical companies continue to advocate for the use of in vitro models towards the reduction of animal use in drug discovery and development while acknowledging that further advancements...
Alternatives to Animal Testing. Alternatives to animal testing will be discussed in more detail in part 2 of this review; they include in vitro tests using cell lines, tissue samples, use of alternative organisms such as bacteria, 3-dimensional modeling and bioprinting, in silico tests, organ-on-chip technologies such as 3-dimensional organoids ...
7 Ιαν 2013 · In vitro techniques focus on the cellular level and therefore cannot replace whole-body testing; determining drug safety and efficacy requires testing in animals. Microfluidic chip testing: Microfluidic chips contain tissue samples from different parts of the body that are linked by microchannels through which a blood substitute flows ...
The range of alternatives includes the following: a) in vitro preparations of many of the major tissues of the human body; b) microphysiological systems, such as single organ and multi-organ chips, with the ultimate goal of creating human-on -a-chip (a human-like mini-organism in vitro), and even ‘you-on-a-chip (focusing on the individual patien...
Microtissue-based in vitro model systems offer a valuable approach to address this issue by accounting for the complexity of natural tissues in a simplified manner. To increase the functionality of these model systems and thus make their use as a substitute for animal testing more likely in the future, the fundamentals need to be continuously ...
