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Microtissue-derived in vitro models are promising candidates to replace animal testing, as they aim to replicate small compartments of the host organ for preclinical studies, rather than focusing on the entire, highly complex organism.
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1 Σεπ 2023 · Various in vitro tests for embryotoxicity (embryonic stem cell test, micromass embryotoxicity assay, and post-implantation rat whole-embryo culture test) are currently in stages of development as screening tests.
Alternatives to Animal Testing. Alternatives to animal testing will be discussed in more detail in part 2 of this review; they include in vitro tests using cell lines, tissue samples, use of alternative organisms such as bacteria, 3-dimensional modeling and bioprinting, in silico tests, organ-on-chip technologies such as 3-dimensional organoids ...
27 Δεκ 2023 · Pharmaceutical companies continue to advocate for the use of in vitro models towards the reduction of animal use in drug discovery and development while acknowledging that further...
27 Σεπ 2016 · In the area of toxicity testing, validation plays an indispensable role: “alternative approaches” are increasingly replacing animal models as predictive tools and it needs to be demonstrated that these novel methods are fit for purpose.
15 Απρ 2021 · The specific use of in vitro models of the liver for nanomaterial genotoxicology testing (10.1002/smll.202006055), and the cardiovascular system to assess myocardial infarction (10.1002/smll.202003765) are then introduced.
23 Σεπ 2021 · Here, we aim to outline a testing strategy for assessing genotoxicity beginning with standard in vitro methods, such as the bacterial reverse mutation test and the in vitro micronucleus test, followed by a second tier of in vitro assays including those using advanced 3D tissue models.
