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  1. Just over a century ago in 1918–1919, the “Spanishinfluenza pandemic appeared nearly simultaneously around the world and caused extraordinary mortality—estimated at 50–100 million fatalities—associated with unexpected clinical and epidemiological features.

  2. 23 Σεπ 2009 · As the threat of the swine flu surfaced in early 2009, doctors and the media referenced the influenza of 1918. Also known as the Spanish flu, this pandemic spread to nearly every part of the world and killed more humans than any other disease in a similar period in known history.

  3. Influenza viruses, including the 1918 pandemic virus, usually cause acute self-limited respiratory infections in humans. Symptoms typically include fever, coryza (inflammation of the nasal mucosa), cough, headache, fatigue, and malaise, often persisting for 7 to 10 days, followed by complete recovery.

  4. 10 Σεπ 2021 · Several epidemiologists have suggested that the Spanish flu virus, possibly originating in Kwangtung province (China), originally started in birds and then, through genetic modification, was transmitted to pigs, leading to swine flu.

  5. 1 Σεπ 2008 · spain. epidemics. pandemics. influenza epidemic. The 1918–1919 influenza pandemic was the most devastating epidemic in modern history. The estimated number of deaths related to the infection worldwide ranged from 20 to >50 million [1–3].

  6. 1 Οκτ 2020 · Just over a century ago in 1918-1919, the "Spanish" influenza pandemic appeared nearly simultaneously around the world and caused extraordinary mortality-estimated at 50-100 million fatalities-associated with unexpected clinical and epidemiological features.

  7. 14 Ιουλ 2021 · Endothelial dysfunction can also cause inflammation, which potentially impacts the cytokine storm caused by influenza viruses . In this review, we summarized the immune mechanisms and pathways behind cytokines in the cytokine storm induced by the influenza virus.

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