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16 Ιουλ 2021 · The choline-inositol-lecithin connection is unique in that it works both ways when it comes to production: the body uses choline and inositol to synthesize lecithin, but it can also operate in reverse, metabolizing choline from lecithin.
The quantitative meta-analysis displayed a significant lowering effect of inositol supplementation on DBP compared with the control group (WMD − 7.12 mmHg; 95% CI − 10.18 to − 4.05, P < 0.001) with significant heterogeneity being noted among the studies (P = 0.65, I 2 = 0.0%) (Fig. 3).
Based on the physiological role of inositols and the pathological implications of altered myo-Ins to D-chiro-Ins ratios, inositol therapy may be designed with two different aims: (1) restoring the inositol physiological ratio; (2) altering the ratio in a controlled way to achieve specific effects.
Myo-inositol, also known as inositol (cyclohexanehexol), is a cyclic carbohydrate with six hydroxyl groups. 1 For a long time, it was considered a B vitamin (vitamin B 8). However, it is not considered an essential nutrient because it is formed from glucose.
In PCOS, the administration of inositol has produced the remission of symptoms as well as a reduction in male hormone secretion 9, a regulation of the cholesterol level, 4 and a more efficient fat breakdown which allow to a significant reduction on body mass and appetite. 10.
Restricted cubic spline (RCS) regression was conducted with 4 default knots located at the 5th, 35th, 65th, and 95th percentiles of dietary choline intake to test the linearity/nonlinearity of the association between choline and CVD.
Myo-Inositol has a relevant role in thyroid function and autoimmune diseases, as a precursor of phosphoinositides that takes part in the phosphatidylinositol (PI) signal transduction pathway.
