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  1. 1 Μαΐ 2023 · INR monitoring is most commonly required for the patients who are on warfarin, a vitamin K antagonist. The dose of warfarin is adapted based on INR scores so that it remains in the therapeutic range to prevent thrombosis from subtherapeutic INR or hemorrhagic complications from supratherapeutic INR.

  2. 5 Οκτ 2024 · Close monitoring of prothrombin time (PT) and the international normalized ratio (INR) is essential to ensure therapeutic effectiveness and minimize adverse events, such as bleeding. This activity reviews the pharmacokinetics, drug interactions, and adverse event profile of warfarin.

  3. 27 Ιουν 2023 · Warfarin is prescribed for people who are at increased risk for developing harmful blood clots. This includes people with a mechanical heart valve, an irregular heart rhythm called atrial fibrillation, certain clotting disorders, or a higher risk of a clot after hip or knee surgery.

  4. 3 Μαρ 2009 · It is important to monitor the INR (at least once a month and sometimes as often as twice weekly) to make sure that the level of warfarin remains in the effective range. If the INR is too low, blood clots will not be prevented, but if the INR is too high, there is an increased risk of bleeding.

  5. 10 Φεβ 2021 · The use of warfarin is declining with preference now being given to direct oral anticoagulants (DOACs) as first-line therapy in common anticoagulation indications, such as VTE treatment and prevention of recurrence, and stroke prevention in non-valvular atrial fibrillation (NVAF).

  6. 18 Απρ 2017 · The time in the therapeutic range (an international normalized ratio [INR] between 2.0 and 3.0) (TTR) has been used as a measure of warfarin (W) therapy quality.

  7. 25 Ιουλ 2024 · Time spent with a prothrombin time/international normalized ratio (PT/INR) above the therapeutic range increases the risk of bleeding, and time spent below the therapeutic range increases the risk of thromboembolic complications.

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