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The use of warfarin is declining with preference now being given to direct oral anticoagulants (DOACs) as first-line therapy in common anticoagulation indications, such as VTE treatment and prevention of recurrence, and stroke prevention in non-valvular atrial fibrillation (NVAF).
For most indications, the therapeutic INR range is 2.0 to 3.0. Exceptions are when war-farin is used for secondary prevention after a myocardial infarction or for patients with high-risk mechanical prosthetic heart valves, in which case the range is 2.5 to 3.5.
a blood clot (thrombosis), your healthcare provider may prescribe warfarin for treatment. Warfarin is a medication that works by blocking the formation of vitamin-K-dependent clotting factors, which are substances in the blood that cause clotting.
This guideline outlines the evidence for managing anticoagulation therapy with oral vitamin K antagonist (warfarin). For dosing and monitoring of warfarin therapy it is recommended that standardized and validated decision support tools be used for most patients.
normalized ratio (INR). • Monitor INR; recommend reduced dosage for an INR above 2 to 3, depending on condition being treated, and an increased dosage for an INR below this range • Monitor PT/INR daily initially and eventually every 2 to 4 weeks. • Expect anticoagulant effects to take 8 to 12 hr, with the full therapeutic effect in 3 to 5 ...
3 Μαρ 2009 · Warfarin (brand names Coumadin and Jantoven) is a prescription medication used to prevent harmful blood clots from forming or growing larger. Beneficial blood clots prevent or stop bleeding, but harmful blood clots can cause a stroke, heart attack, deep vein thrombosis, or pulmonary embolism.
When appropriately managed in compliant stable patients, warfarin is safe & effective safety & effectiveness ↑ as time in therapeutic range ↑. MANAGEMENT PEARLS •Use a validated nomogram for initiating & maintaining warfarin.
