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  1. 28 Ιουν 2012 · Iodine requirements are increased ≥50% during pregnancy. Iodine deficiency during pregnancy can cause maternal and fetal hypothyroidism and impair neurological development of the fetus. The consequences depend upon the timing and severity of the hypothyroidism; the most severe manifestation is cretinism.

  2. The World Health Organization (WHO) recently increased their recommended iodine intake during pregnancy from 200 to 250 μg/d and suggested that a median urinary iodine (UI) concentration of 150–249 μg/L indicates adequate iodine intake in pregnant women.

  3. 28 Ιουλ 2021 · Maternal severe iodine deficiency is associated with adverse pregnancy outcomes such as miscarriage, stillbirth, neonatal mortality, and growth retardation. It also affects neonatal and offspring development since thyroid hormone is essential for normal brain development (10, 11).

  4. 1 Ιαν 2020 · Severe iodine deficiency during pregnancy is associated with a greater incidence of stillbirths, abortions, and congenital abnormalities. 3 Iodine prophylaxis with iodized oil in pregnant women in areas of severe deficiency reduces fetal and perinatal mortality. 26 The fetal brain is particularly vulnerable to iodine deficiency.

  5. WHO and UNICEF recommend iodine supplementation for pregnant and lactating women in countries where less than 20% of households have access to iodized salt, until the salt iodization programme is scaled up.

  6. Well-designed, prospective, randomized controlled trials that examine the effects of iodine supplementation on maternal thyroid function and infant neurobehavioral development in mildly to moderately iodine-deficient pregnant women are urgently needed.

  7. 22 Ιουν 2022 · This review highlights the sources of iodine, role of iodine in thyroid physiology, measurement tools of assessing iodine status, the consequences of iodine deficiency and excess, and evidence to date of iodine supplementation in pregnant women.

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