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Magnesium also affects blood pressure and endothelial function. Higher serum magnesium concentration is associated with improved endothelial dysfunction in patients with CKD, demonstrated by increased flow-mediated dilation of the brachial artery [36,109].
28 Ιουλ 2017 · In this context, a recent study showed that Mg acts protectively against phosphate-induced kidney injury, 8 which may involve suppression of phosphate-mediated tubular cell apoptosis, prevention of nephrocalcinosis and renal artery calcification, and inhibition of tubular calcium phosphate crystallization. However, in this study, improvement of ...
12 Μαΐ 2015 · Key Points. Maintenance of normal serum levels of magnesium depends on net absorption in the gut, uptake by and release from bone, and net excretion in the kidney. Patients with advanced...
As such, magnesium potentially has a major influence on the pathogenesis of cardiovascular disease. As the kidney is a major regulator of magnesium homeostasis, kidney disorders can potentially lead to both magnesium depletion and overload, and as such increase the risk of cardiovascular disease.
10 Ιαν 2018 · Sakaguchi Y, Iwatani H, Hamano T, Tomida K, Kawabata H, Kusunoki Y, et al. Magnesium modifies the association between serum phosphate and the risk of progression to end-stage kidney disease in patients with non-diabetic chronic kidney disease.
12 Φεβ 2020 · Magnesium disorders are commonly encountered in chronic kidney disease (CKD) and are typically a consequence of decreased kidney function or frequently prescribed medications such as diuretics and proton pump inhibitors.
Magnesium impairs the crystallization of calcium phosphate—more specifically, the maturation of calciprotein particles. Considering that phosphate overload causes kidney damage, magnesium might counteract the phosphate toxicity to the kidney, as in the case of vascular calcification.
