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Thirty-seven patients with chronic, stable angina pectoris were included in a randomized, double-blind cross-over study to assess the efficacy of once- and twice-daily dosage regimens of 60 mg isosorbide-5-mononitrate, in a controlled-release formulation (5-ISMN Durules, Astra).
- Isosorbide - StatPearls - NCBI Bookshelf
FDA Approved Indications for Isosorbide Mononitrate....
- Isosorbide - StatPearls - NCBI Bookshelf
4 Αυγ 2023 · Consider 5 mg twice daily for small statured patients; increase to at least 10 mg twice daily in first 2 to 3 days. Asymmetric dosing (7 hours apart) provides a nitrate-free interval to minimize tolerance. Start at the low end of the dosing range for elderly patients.
Angina Pectoris. Prevention of angina pectoris caused by coronary artery disease. Immediate release: 5-10 mg PO twice daily initially (5 mg in small patients) given each dose 7 hr apart;...
16 Μαΐ 2023 · FDA Approved Indications for Isosorbide Mononitrate. Treatment of chronic angina pectoris due to coronary artery disease. Along with non-selective beta-blockers (NSBB), it can be used as secondary prophylaxis in preventing recurrent variceal hemorrhage. [6]
Isosorbide mononitrate (ISMN) is widely used for the prophylaxis of angina pectoris. As the active metabolite of isosorbide dinitrate, ISMN does not require first-pass metabolism for activation and its longer half-life allows for twice-daily dosing.
Angina. Isosorbide dinitrate or mononitrate is used for the acute relief of angina pectoris, for prophylactic management in situations likely to provoke angina attacks, and for long-term prophylactic management of angina pectoris.
For prevention of angina: For oral dosage form (extended-release tablets): Adults—At first, 30 or 60 milligrams (mg) once a day. Take the dose in the morning right after you wake up. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage form (tablets):
