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27 Μαρ 2024 · Multiple myeloma is a blood cancer that affects plasma cells. In light chain myeloma, cancerous plasma cells create a specific type of immunoglobulin known as light chains. Healthy plasma cells...
27 Αυγ 2024 · For a specific diagnosis of light chain multiple myeloma, a blood test called serum-free light chain must show a particular level of excess light chains. Urine tests may also confirm the presence of light chains.
Monoclonal proteins can be either intact monoclonal immunoglobulins or immunoglobulin light chains (Bence Jones proteins) found in the blood and/or urine. If there are not CRAB signs and/or symptoms, 60% plasma cells in the bone marrow indicates a diagnosis.
People with multiple myeloma typically have abnormally high levels of either kappa or lambda light chain, and an abnormal ratio between the two light chains. You will have imaging studies to evaluate for bone or other abnormalities. These studies could include X-rays, MRI, CT, and/or PET-CT imaging.
31 Μαΐ 2022 · Light chain multiple myeloma is a subtype of multiple myeloma, a cancer of the plasma cells in bone marrow. Read about light and heavy chains, diagnosis, and treatment.
There is a urine test which can detect the light chains (Bence Jones protein) in your urine. A blood test can also pick up small increases in the amount of free light chains in the blood. This is called a serum free light chain test. Doctors use this test to: Your doctor can use the test to diagnose and monitor your myeloma.
Light chains in the urine are commonly known as Bence Jones proteins (BJP). The majority of patients have IgG type myeloma. IgA is the next most common, with IgM, IgD and IgE types all rare. Around 20% of patients have light chain myeloma, where the myeloma cells produce only light chains and no whole immunoglobulins.
