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  1. Iron sucrose injection is an iron replacement product that is used to treat iron deficiency anemia (not enough iron in the blood) in patients with chronic kidney disease (CKD). Iron is a mineral that the body needs to produce red blood cells.

  2. We explored potential sources of heterogeneity: type of IV iron preparation, comparator (placebo, oral, no iron, IM iron, or other), indication for iron therapy, adequacy of collecting and reporting methods of the AEs, and the adequacy of allocation generation, concealment, and masking.

  3. Iron dextran is an iron replacement product that is used to treat iron deficiency, such as anemia (not enough iron in the blood) or blood loss in patients with certain conditions (eg, hemophilia, gastrointestinal bleeding). Iron is a mineral that the body needs to produce red blood cells.

  4. Abstract. Objective: To amass all available evidence regarding the safety of intravenous (IV) iron preparations to provide a true balance of efficacy and safety. Methods: Systematic review and meta-analysis of all randomized clinical trials comparing IV iron to another comparator.

  5. Ferumoxytol injection is an iron replacement product that is used to treat iron deficiency anemia (not enough iron in the blood) in patients with chronic kidney disease (CKD) and in patients unable to take oral iron or who had taken oral iron in the past but did not work well.

  6. 5 Νοε 2021 · The major adverse effect associated with IV iron is infusion-related reactions (IRR), ranging from mild reactions mediated by complement activation-related pseudo-allergy to anaphylaxis. In this study, we sought to determine rates and severity of iron IRR, identify patient characteristics associated with IRR and report strategies for subsequent ...

  7. Severe infusion reactions were more common with IV iron (RR, 2.47; 95% CI, 1.43-4.28; I(2)=0%). There was no increased risk of infections with IV iron. Gastrointestinal AEs were reduced with IV iron. Conclusion: Intravenous iron therapy is not associated with an increased risk of SAEs or infections. Infusion reactions are more pronounced with ...

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