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17 Αυγ 2023 · Cephalexin is commonly utilized in the treatment of urinary tract infections, respiratory infections, otitis media, bone infections caused by Staphylococcus aureus or Proteus mirabilis, and skin and soft tissue infections primarily caused by S aureus or Streptococcus pyogenes.
17 Φεβ 2024 · However, cefotaxime has a broad therapeutic index, suggesting that dosage adjustments may not be necessary for hepatic impairment. In the context of spontaneous bacterial peritonitis therapy, cefotaxime's comprehensive coverage and high ascitic fluid concentrations make it a preferred antibiotic.
KEFLEX is indicated for the treatment of otitis media caused by susceptible isolates of Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyogenes, and...
The therapeutic index (TI) is the range of doses at which a medication is effective without unacceptable adverse events. Drugs with a narrow TI (NTIDs) have a narrow window between their effective doses and those at which they produce adverse toxic effects.
KEFLEX ® (cephalexin) Capsules, USP is a semisynthetic cephalosporin antibacterial drug intended for oral administration. It is 7-(D-α-Amino-α-phenylacetamido)-3-methyl-3-cephem-4-carboxylic acid monohydrate.
4 Αυγ 2021 · At present, the FDA does not designate specific drugs as Narrow Therapeutic Index's. However, in the Code of Federal Regulation (21 CFR 320.33c), the FDA has provided a definition for drugs with a narrow therapeutic ratio based on median lethal and effective doses. This definition is as follows:
The literature review demonstrated that flecainide displays NTID characteristics including a steep drug dose–response relationship for safety and efficacy, a need for therapeutic drug monitoring of pharmacokinetic (PK) or pharmacodynamics measures and intra-subject variability in its PK properties.
