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29 Οκτ 2020 · Recent studies have demonstrated the potential of natural killer (NK) cells in immunotherapy to treat multiple types of cancer. NK cells are innate lymphoid cells that play essential roles in...
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15 Δεκ 2022 · Programmed death ligand-2 (PD-L2), a PD-1 ligand, mediates cancer cell immune escape (or tolerance independent of PD-L1) and predicts poor prognosis of patients with HNSCC.
23 Αυγ 2024 · Facts. NK cells are first line defenders in cancer, by natural cytotoxicity and by mediating ADCC making them crucial components for cancer immunosurveillance. NK cells have at their disposal...
16 Μαρ 2023 · Further analysis showed that PD-L2 expression was strongly associated with the infiltration of immune cells in tumor tissue in almost all cancer types, among which macrophages were the most positively associated with PD-L2 in colon cancer.
The discovery of immune checkpoints (ICs) and the development of specific blockers to relieve immune effector cells from this inhibiting mechanism has changed the view of anti-cancer therapy. In addition to cytotoxic T lymphocyte antigen 4 (CTLA4) and programmed death 1 (PD1), classical ICs of T lymphocytes and recently described also on a ...
31 Ιαν 2024 · PD-L2 is mainly expressed in antigen-presenting cells but can be induced to express on the surface of tumor cells under the influence of inflammatory cytokines. Several studies have shown significant remissions in patients with metastatic melanoma and non-small cell lung cancer after 12 and 16 cycles of treatment with anti-PD-1/PD-L1 antibodies ...
1 Ιουλ 2020 · Programmed cell death-ligand 2 (PD-L2) is one of the two ligands of the programmed cell death-1 (PD-1) receptor, an inhibitory protein mainly expressed on activated immune cells that is...
