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11 Φεβ 2019 · The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal, differentiation...
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Mesenchymal stromal cells (MSCs) are cells that localize adjacent to blood vessels in bone marrow and are thought to be primitive cells capable of differentiation into osteolineage cells, chondrocytes, and adipocytes.
15 Ιαν 2014 · This paper is a systematic analysis of CXCL12-expressing cells in the bone marrow, demonstrating the specific role of primitive mesenchymal cells and endothelial cells in regulating HSC...
6 Μαΐ 2024 · The bone marrow is a complex organ that houses diverse cells from the hematopoietic, mesenchymal, endothelial, vascular smooth muscle, and neural lineages. 1 Relatively rare non-hematopoietic cells are known to make critical contributions to hematopoiesis. 2 Many non-hematopoietic cell types, including endothelial cells (ECs), mesenchymal ...
13 Ιαν 2017 · Abstract. Bone marrow (BM) is a source of hematopoietic stem cells (HSCs). HSCs are localized in both the endosteum, in the so-called endosteal niche, and close to thin-walled and fenestrated sinusoidal vessel in the center of BM, in the so-called vascular niche. HSCs give rise to all types of mature blood cells through a process finely ...
1 Φεβ 2010 · Notch signaling is important throughout development and also appears to play a critical role in cellular maturation and differentiation of osteoblastic cells and hematopoietic cells as disregulation can lead to bone loss and leukemias, respectively.
Many of these mechanisms are intrinsic to the HSCs. However, as early as the 1970s, scientists have proposed that the local bone marrow (BM) microenvironment, referred to as the “niche,” also provides crucial and indispensable factors for HSC self-renewal and differentiation.
