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13 Ιαν 2017 · Bone marrow (BM) is a source of hematopoietic stem cells (HSCs). HSCs are localized in both the endosteum, in the so-called endosteal niche, and close to thin-walled and fenestrated sinusoidal vessel in the center of BM, in the so-called vascular niche.
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Knowledge of specific factors that regulate adult murine and...
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15 Ιαν 2014 · Postnatally, the bone marrow is the primary site of HSC maintenance and haematopoiesis, but in response to haematopoietic stress the niche can shift to extramedullary sites.
30 Οκτ 2023 · This tissue is known as bone marrow and is responsible for the production of blood cells – a process known as hematopoiesis. This article will review the embryology of the bone marrow as well as its histology.
11 Φεβ 2019 · The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal, differentiation...
26 Νοε 2015 · The bone marrow niche is a unique microenvironment that integrates the physiology of the skeleton and the marrow to maintain the haematopoietic stem cell pool and support whole-organism...
1 Μαρ 2022 · Angiogenesis, hematopoiesis and osteogenesis are fundamental processes mediating complex and essential biological functions. In the bone marrow, endothelial cells (ECs) are a principal mediator of regulatory signals that govern hematopoietic and mesenchymal stem cells. EC and osteoblast interactions and niche functions of ECs are fundamental in ...
Bones generally consist of a hard calcified exterior (known as cortical or compact bone) and an inner core of trabecular or cancellous bone containing marrow with hematopoietic stem and progenitor cells.
