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Some report demonstrated a significant association between the severity of the disorder and the abnormalities in Hcy levels. Conclusion: Further research is needed to correlate the increase in Hcy with specific symptoms/ deficits in ASD and to evaluate the clinical impact of strategies that can reduce Hcy concentration in ASD.
1 Σεπ 2020 · Thirty-one studies (3304 participants including 1641 cases) were included. The pooled results showed that the peripheral blood Hcy levels were significantly elevated in children with ASD when compared to HC (Hedges's g = 0.56, 95% CI = 0.36 to 0.76, P < 0.001).
1 Ιαν 2018 · To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation. Increased homocysteine levels correlate with the communication deficit in children with autism spectrum disorder.
1 Ιουλ 2020 · The RCS model indicated a positive and linear association between serum homocysteine and the risk of ASD. The lowest quartile of folate was positively associated with ASD severity (OR: 4.227,...
It was suggested that autistic children had lower plasma LXA4 levels, suggesting an increased susceptibility to recurring inflammation in these samples, and a significant negative relationship between circulating LXA 4 levels and severity of autism evaluated by Childhood Autism Rating Scale scores.
12 Φεβ 2018 · The results suggest that high fasting serum homocysteine and low folate and vitamin B(12) levels could be used as clinical biomarkers for an early diagnosis and management of ASD.
Keywords: Autism spectrum disorder, core symptoms, metabolism, homocysteine, language development, biomarker. Abstract: Background and Objective: Homocysteine (Hcy) is a non-protein α-amino acid, which plays several important roles in human physiology and in the central nervous system.
