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Conclusion: Further research is needed to correlate the increase in Hcy with specific symptoms/ deficits in ASD and to evaluate the clinical impact of strategies that can reduce Hcy concentration in ASD. Keywords: Autism spectrum disorder; biomarker; core symptoms; homocysteine; language development; metabolism..
15 Αυγ 2022 · The serum levels of homocysteine were significantly higher (p = 0.0048) in the ASD group than in the control group, while the serum levels of folate (p = 0.003) and vitamin B12 (p = 0.0048) were lower in the ASD group (Figure 1A).
Reduction of homocysteine levels has been most readily accomplished by supplementation of the diet with the B vitamins (folate, vitamins B 6 and B 12); reductions of up to 39% have been reported. 16 Other therapies, including methionine restriction and exercise training, have also shown modest effects in reducing levels of homocysteine. 17
6 Ιαν 2018 · There's no evidence that special diets are an effective treatment for autism spectrum disorder. And for growing children, restrictive diets can lead to nutritional deficiencies. If you decide to pursue a restrictive diet, work with a registered dietitian to create an appropriate meal plan for your child.
1 Σεπ 2020 · Results of studies on peripheral blood levels of homocysteine (Hcy) in children with autism spectrum disorder (ASD) are inconsistent, and conclusions from two previous meta-analyses on this subject published in 2012 are already outdated.
12 Φεβ 2018 · The higher level of homocysteine in autistic children may indicate deficiencies of folic acid and vitamins B₆ and B₁₂ in nutrition of these children.
The pooled results showed that the peripheral blood Hcy levels were significantly elevated in children with ASD when compared to HC (Hedges's g = 0.56, 95% CI = 0.36 to 0.76, P < 0.001). By sensitivity analyses, we confirmed that our results were quite robust.
