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Conclusion: Further research is needed to correlate the increase in Hcy with specific symptoms/ deficits in ASD and to evaluate the clinical impact of strategies that can reduce Hcy concentration in ASD. Keywords: Autism spectrum disorder; biomarker; core symptoms; homocysteine; language development; metabolism..
CONTEXT: Children with autism spectrum disorder (ASD) frequently use special diets or abstract receive nutritional supplements to treat ASD symptoms. OBJECTIVES: Our objective was to evaluate the effectiveness and safety of dietary interventions or nutritional supplements in ASD. DATA SOURCES: Databases, including Medline and PsycINFO.
26 Δεκ 2019 · Moreover, lower GSH levels in the GI tract can promote inflammation and contribute to symptoms of GI discomfort and dysfunction. Thus, a GFCF diet may provide clinical benefit by improving CYS absorption and GSH levels, particularly in individuals with low GSH levels, as is the case in ASD.
1 Σεπ 2020 · Results of studies on peripheral blood levels of homocysteine (Hcy) in children with autism spectrum disorder (ASD) are inconsistent, and conclusions from two previous meta-analyses on this subject published in 2012 are already outdated.
12 Φεβ 2018 · The higher level of homocysteine in autistic children may indicate deficiencies of folic acid and vitamins B₆ and B₁₂ in nutrition of these children.
Overall, an increased homocysteine level was associated with ASD in a linear manner and is thus a novel diagnostic biomarker for ASD, suggesting that homocy steine-lowering interventions or folate and vitamin B12 supplementation might be a viable treatment strategy for ASD.
12 Μαρ 2024 · In the ASD cohort, we observed a correlation between the severity of Autism Spectrum Disorder (ASD), as assessed by the Childhood Autism Rating Scale (CARS) score, and serum levels of IL-17 A, homocysteine (Hcy), folate, and vitamin B12.
