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Memory B cells are mature B cells that have encountered antigen that have been activated but not tolerated and have switched to higher-affinity isotypes. IgM-secreting plasma cells, Syndecan-1/CD138+, are terminal cells destined to die. It is not known how memory B cells develop in vivo.
Classically, memory B cells are defined as non-dividing, antigen-primed, mainly GC-derived, long-lived, class-switched, and somatically hyper-mutated B cells with potential for a rapid reactivation and differentiation into antibody-secreting plasma cells (Kurosaki et al., 2015; Rao et al., 2015 ).
1 Ιαν 2024 · Immunological memory provided by memory B cells (MBCs), memory T cells and long-lived (memory) plasma cells (PCs) yields long-lasting, effective cellular and humoral immune protection to previously encountered pathogens and vaccines.
We comprehensively review memory B cells (MBCs), covering the definition of MBCs and their identities and subsets, how MBCs are generated, where they are localized, how they are maintained, and how they are reactivated.
19 Μαρ 2024 · Memory B cells are long-lived B cells that arise during the initial adaptive response to a pathogen, in order to generate a rapid and robust response in the event of a repeat exposure to the same antigen.
3 Ιουλ 2023 · This Review discusses the cellular and molecular mechanisms of memory B cell generation and reactivation and how these processes shape antibody diversity and breadth.
7 Μαρ 2024 · Studies have been conducted in vitro and using advanced animal models to elucidate the mechanism underlying the generation of memory B cells (MBCs), the precise roles of MBCs against...
