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  1. Insulin resistance during pregnancy is accentuated in situations with diabetes, obesity, and inactivity and can become a serious condition with important implications for pregnancy outcome and long-term morbidity for the mother and offspring.

  2. The physiology of insulin resistance during pregnancy is fas-cinating, from an evolutionary point of view designed to limit maternal glucose utilization and thereby shunt an adequate amount of supply to the growing fetus, which requires most of its energy source as glucose.

  3. Background: Purpose of insulin resistance (IR) adapted by mother is to deliver enough quantity of nutrients to the growing fetus. Many maternal hormones and factors play role in causation of IR during pregnancy. Aim: The study aims at evaluating IR at different trimesters of pregnancy.

  4. 27 Μαΐ 2021 · We report a rare and clinically difficult case of extreme insulin resistance with daily insulin requirements of 1420 IU/day during pregnancy in an obese 36-year-old woman with type 2 diabetes (T2D) and polycystic ovary syndrome (PCOS).

  5. Gestational diabetes and obesity are the common metabolic abnormalities occurring during pregnancy. Decreased maternal pregravid insulin sensitivity (insulin resistance) coupled with an inadequate insulin response are the pathophysiological mechanisms underlying the development of gestational diabetes.

  6. 25 Οκτ 2024 · Metformin is an effective oral hypoglycaemic agent used in the treatment of type 2 diabetes mellitus; however, its use in pregnancy for the treatment of gestational diabetes mellitus (GDM) remains ...

  7. 23 Ιουλ 2021 · This study aimed to explore the relationship between insulin resistance (IR) and adverse pregnancy outcomes in women with gestational diabetes mellitus (GDM), and to determine the risk factors for IR in women with GDM.

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