Αποτελέσματα Αναζήτησης
Insulin resistance during pregnancy is accentuated in situations with diabetes, obesity, and inactivity and can become a serious condition with important implications for pregnancy outcome and long-term morbidity for the mother and offspring.
The physiology of insulin resistance during pregnancy is fas-cinating, from an evolutionary point of view designed to limit maternal glucose utilization and thereby shunt an adequate amount of supply to the growing fetus, which requires most of its energy source as glucose.
Background: Purpose of insulin resistance (IR) adapted by mother is to deliver enough quantity of nutrients to the growing fetus. Many maternal hormones and factors play role in causation of IR during pregnancy. Aim: The study aims at evaluating IR at different trimesters of pregnancy.
19 Νοε 2019 · The physiology of insulin resistance during pregnancy is fascinating, from an evolutionary point of view designed to limit maternal glucose utilization and thereby shunt an adequate amount of supply to the growing fetus, which requires most of its energy source as glucose.
25 Οκτ 2024 · Metformin is an effective oral hypoglycaemic agent used in the treatment of type 2 diabetes mellitus; however, its use in pregnancy for the treatment of gestational diabetes mellitus (GDM) remains ...
Metformin crosses the placenta 7 and might also lower glucose and insulin resistance in the fetus, leading to reductions in the number of infants who are large for gestational age and other fetal morbidities, such as neonatal hypoglycaemia 8 and respiratory distress syndrome, and pregnancy loss.
Although metformin has the potential to counteract gestational insulin resistance (which stands at the core of GDM pathophysiology), there is much uncertainty about its use during pregnancy, so that international guidelines differ in their recommendations.
