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10 Φεβ 2020 · Mechanism of Action. Increases the tone, rate and amplitude of contractions on the smooth muscles of the uterus, producing sustained contractions which shortens the third stage of labor and reduces blood loss.
Methergine (methylergonovine maleate) acts directly on the smooth muscle of the uterus and increases the tone, rate, and amplitude of rhythmic contractions. Thus, it induces a rapid and sustained...
Mechanism of Action. Produces vasoconstriction to increase strength, duration, & frequency of uterine contraction which in turn impedes uterine blood flow. Pharmacokinetics. Bioavailability:...
Mechanism: 5-HT agonist; acts directly on myometrium to increase tone, rate, and amplitude of contractions: Dosage with Qualifiers: Postpartum bleeding—emergent: 0.2mg IM q2-4h; max 5 doses; nonemergent: 0.2-0.4mg PO q6-12h; max duration 7d • Contraindications—hypersensitivity to drug or class, hypertension, toxemia, pregnancy • Caution ...
Find information on Methylergonovine (Methergine) in Davis’s Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.
Mechanism Of Action and Pharmacodynamic Effects : This drug appears to have multiple molecular targets, including adrenoceptors, dopamine receptors, and 5-HT receptors, although the exact mechanism of action remains unclear.
Mechanism of Action. Increases uterine contraction force and frequency; Comments See Also. Postpartum hemorrhage; References