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What are the benefits of taking methotrexate for a person with lupus? • Methotrexate treats joint pain and swelling in lupus patients. It can also treat the butterfly rash on the face (called malar rash). It is sometimes used to treat inflammation around the heart (called pericarditis) or around the lungs. How long does methotrexate take to work?
OBJECTIVE: The objective of this review is to evaluate the evidence for efficacy of methotrexate (MTX) in systemic lupus erythematosus (SLE). METHODS: A comprehensive, computerized search was performed in MEDLINE (PubMed), EMBASE and the Cochrane Controlled Trials registry to screen for studies that examined the efficacy of MTX in adult SLE ...
Methotrexate is one of the most commonly used drugs for the treatment of rheumatoid arthritis, and it is used in lupus patients to alleviate the joint pain and swelling of polyarthritis (arthritis involving multiple joints).
29 Οκτ 2013 · Additional glucocorticoids and cytotoxic agents—such as azathioprine, mycophenolate mofetil, cyclophosphamide, cyclosporine and methotrexate —are used for SLE with specific organ manifestations.
7 Ιαν 2014 · All of the included studies predominantly involved patients with arthritis or mucocutaneous features. There was significant reduction of the SLE Disease Activity Index (SLEDAI) among MTX-treated patients when compared with controls ( p = 0.001, odds ratio (OR) 0.444, 95% confidence interval (CI) 0.279 to 0.707).
Conclusion: The use of MTX is associated with significant reductions in SLEDAI and the average dose of corticosteroids in adult patients with SLE. Keywords: SLE; Systemic lupus erythematosus; efficacy; lupus; methotrexate.
Apart from its use in rheumatoid arthritis, MTX has been assessed in small studies in patients with vasculitis, uveitis, and inflammatory bowel disease. The aim of this study was to evaluate the efficacy of MTX in a particular group of patients with systemic lupus erythematosus (SLE).
