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11 Αυγ 2024 · Methylprednisolone is a systemic synthetic corticosteroid that exerts a wide range of physiologic effects similar to naturally occurring glucocorticoids. Methylprednisolone is typically prescribed due to its anti-inflammatory and immunosuppressive activity in the human body.
11 Αυγ 2024 · Methylprednisolone is an FDA-approved medication used for managing and treating various conditions, including allergic reactions, arthritis, asthma exacerbations, long-term asthma maintenance, and acute exacerbations of multiple sclerosis.
4 Αυγ 2022 · Some studies have found that pulsed intravenous methylprednisolone (MP-Pulse) is a feasible therapy for active SSc. 7, 8 However, repeated MP-Pulse therapy can increase the risk of adverse reactions. 9, 10 The adverse effects of glucocorticoids are extensive and can involve many organ systems.
23 Οκτ 2021 · Abstract. The temporal variations in the pharmacokinetics and pharmacodynamics of methylprednisolone at 8 am versus 4 pm were investigated in six healthy male volunteers. Subjects completed three phases: no drug administration, 20 mg intravenous methylprednisolone at 8 am, and the same dose at 4 pm. Methylprednisolone clearance was 28% greater ...
9 Απρ 2021 · Methylprednisolone is an option for treating ARDS. However, the benefits and adverse effects of methylprednisolone have not been well assessed in patients with ARDS. This study aimed to evaluate the efficacy and safety of methylprednisolone against ARDS.
4 Ιουν 2021 · These data suggest that methylprednisolone is associated with reduced hypercoagulation, although it remains unclear whether corticosteroids reduce hypercoagulation directly, indirectly through reducing inflammatory mediators, or both.
Objective: To determine the effects of low-dose prolonged methylprednisolone infusion on lung function in patients with early severe ARDS. Design: Randomized, double-blind, placebo-controlled trial. Setting: ICUs of five hospitals in Memphis.
