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11 Αυγ 2024 · As an anti-inflammatory, methylprednisolone is 5 times as potent as hydrocortisone (cortisol) while demonstrating minimal mineralocorticoid activity. Methylprednisolone diffuses passively across the cellular membrane and binds to the intracellular glucocorticoid receptor.
11 Αυγ 2024 · Methylprednisolone is an FDA-approved medication used for managing and treating various conditions, including allergic reactions, arthritis, asthma exacerbations, long-term asthma maintenance, and acute exacerbations of multiple sclerosis.
23 Οκτ 2021 · Abstract. The temporal variations in the pharmacokinetics and pharmacodynamics of methylprednisolone at 8 am versus 4 pm were investigated in six healthy male volunteers. Subjects completed three phases: no drug administration, 20 mg intravenous methylprednisolone at 8 am, and the same dose at 4 pm. Methylprednisolone clearance was 28% greater ...
5 Σεπ 2015 · We randomly assigned 100 patients to oral methylprednisolone and 99 patients to intravenous methylprednisolone with a mean time from relapse onset to treatment of 7·0 days (SD 3·6) and 7·4 days (3·9), respectively.
Within a 24-h interval, two dose fractions of methylprednisolone produce a stronger and more sustained immunosuppressive response than one single bolus dose.
18 Δεκ 2021 · All the patients started receiving off-label treatment with IV methylprednisolone pulse 500 mg/day for 3 days, followed by oral methylprednisolone 1 mg/kg once daily, then tapered by 10−20 mg/day and finishing with 10mg.
10 Απρ 2021 · An event is serious (based on the ICH definition) when the patient outcome is: A 75-year-old man exhibited lack of efficacy during treatment with methylprednisolone for autoimmune haemolytic anaemia and COVID-19 cytokine storm. The man presented with complaints of weakness and dyspnoea.
