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11 Αυγ 2024 · As an anti-inflammatory, methylprednisolone is 5 times as potent as hydrocortisone (cortisol) while demonstrating minimal mineralocorticoid activity. Methylprednisolone diffuses passively across the cellular membrane and binds to the intracellular glucocorticoid receptor.
23 Οκτ 2021 · Abstract. The temporal variations in the pharmacokinetics and pharmacodynamics of methylprednisolone at 8 am versus 4 pm were investigated in six healthy male volunteers. Subjects completed three phases: no drug administration, 20 mg intravenous methylprednisolone at 8 am, and the same dose at 4 pm. Methylprednisolone clearance was 28% greater ...
11 Αυγ 2024 · Methylprednisolone is an FDA-approved medication used for managing and treating various conditions, including allergic reactions, arthritis, asthma exacerbations, long-term asthma maintenance, and acute exacerbations of multiple sclerosis.
Relapses of multiple sclerosis (MS) are treated commonly with high-dose intravenous methylprednisolone (MP) given over a period of 3–5 days. The mechanisms responsible for the beneficial effects of MP in attacks are not clearly established.
Abstract. The efficacy of glucocorticoid for treatment of acute spinal cord injuries remains a controversial topic. Differing medical societies have issued conflicting recommendations in this regard. Here we review the available randomized, controlled trial (RCT) data on this subject and offer a synthesis of these data sets.
18 Δεκ 2021 · All the patients started receiving off-label treatment with IV methylprednisolone pulse 500 mg/day for 3 days, followed by oral methylprednisolone 1 mg/kg once daily, then tapered by 10−20 mg/day and finishing with 10mg. Methylprednisolone was given as single dose in the morning.
Conclusion: Within a 24-h interval, two dose fractions of methylprednisolone produce a stronger and more sustained immunosuppressive response than one single bolus dose.
