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11 Αυγ 2024 · Methylprednisolone is a systemic synthetic corticosteroid that exerts a wide range of physiologic effects similar to naturally occurring glucocorticoids. Methylprednisolone is typically prescribed due to its anti-inflammatory and immunosuppressive activity in the human body.
11 Αυγ 2024 · Methylprednisolone is an FDA-approved medication used for managing and treating various conditions, including allergic reactions, arthritis, asthma exacerbations, long-term asthma maintenance, and acute exacerbations of multiple sclerosis.
To study the use of high-dose oral methylprednisolone compounded formulation and intravenous methylprednisolone for the treatment of multiple sclerosis relapses. To compare both routes of methylprednisolone administration related to cost and patient’s satisfaction with the treatment.
27 Αυγ 2019 · Methylprednisolone. Based on the current evidence, high-dose MP treatment, in comparison to controls, does not contribute to better neurologic recoveries but may increase the risk of adverse events in patients with ASCI. Therefore, we recommend against routine use of high-dose MP early after ASCI.
23 Οκτ 2021 · Abstract. The temporal variations in the pharmacokinetics and pharmacodynamics of methylprednisolone at 8 am versus 4 pm were investigated in six healthy male volunteers. Subjects completed three phases: no drug administration, 20 mg intravenous methylprednisolone at 8 am, and the same dose at 4 pm. Methylprednisolone clearance was 28% greater ...
18 Δεκ 2021 · All the patients started receiving off-label treatment with IV methylprednisolone pulse 500 mg/day for 3 days, followed by oral methylprednisolone 1 mg/kg once daily, then tapered by 10−20 mg/day and finishing with 10mg. Methylprednisolone was given as single dose in the morning.
1 Μαρ 2022 · Methylprednisolone inhibits the proliferation and affects the differentiation of rat spinal cord-derived neural progenitor cells cultured in low oxygen conditions by inhibiting HIF-1α and Hes1 in vitro.
