Αποτελέσματα Αναζήτησης
11 Αυγ 2024 · Methylprednisolone is an FDA-approved medication used for managing and treating various conditions, including allergic reactions, arthritis, asthma exacerbations, long-term asthma maintenance, and acute exacerbations of multiple sclerosis.
23 Οκτ 2021 · Abstract. The temporal variations in the pharmacokinetics and pharmacodynamics of methylprednisolone at 8 am versus 4 pm were investigated in six healthy male volunteers. Subjects completed three phases: no drug administration, 20 mg intravenous methylprednisolone at 8 am, and the same dose at 4 pm. Methylprednisolone clearance was 28% greater ...
Evidence points to the host’s inability to fully down-regulate systemic inflammation and restore tissue homeostasis as the dominant pathophysiologic processes contributing to acute and chronic adverse outcomes in community-acquired pneumonia (CAP) [9, 10].
Within a 24-h interval, two dose fractions of methylprednisolone produce a stronger and more sustained immunosuppressive response than one single bolus dose.
10 Απρ 2021 · An event is serious (based on the ICH definition) when the patient outcome is: A 75-year-old man exhibited lack of efficacy during treatment with methylprednisolone for autoimmune haemolytic anaemia and COVID-19 cytokine storm. The man presented with complaints of weakness and dyspnoea.
17 Απρ 2021 · A 36-year-old woman developed an extended-spectrum B-lactamase-producing Escherichia Coli infection and bacterial abscess during treatment with methylprednisolone for hyperinflammatory syndrome. The woman presented to the emergency department with fever, thoracic pain and cough.
Pulse IV methylprednisolone therapy is the intermittent administration of supraphysiological quantities of the drug to enhance its therapeutic effects while reducing its toxic effects. 1 A typical pulse regimen ranges from 500 to 1000 mg IV daily for 2–4 consecutive days. 1, 2 It has been suggested that methylprednisolone may cause an acute ...
