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11 Αυγ 2024 · Methylprednisolone is a systemic synthetic corticosteroid that exerts a wide range of physiologic effects similar to naturally occurring glucocorticoids. Methylprednisolone is typically prescribed due to its anti-inflammatory and immunosuppressive activity in the human body.
11 Αυγ 2024 · Methylprednisolone is an FDA-approved medication used for managing and treating various conditions, including allergic reactions, arthritis, asthma exacerbations, long-term asthma maintenance, and acute exacerbations of multiple sclerosis.
Although similar to prednisone and prednisolone, methylprednisolone has even less mineralocorticoid activity and, therefore, may be preferred when mineralocorticoid effects ... Osteonecrosis develops in 9–40% of adult patients receiving long-term GC therapy; ... Time until onset is at least 1 year with doses ≥10 mg/day of oral prednisone ...
23 Οκτ 2021 · Abstract. The temporal variations in the pharmacokinetics and pharmacodynamics of methylprednisolone at 8 am versus 4 pm were investigated in six healthy male volunteers. Subjects completed three phases: no drug administration, 20 mg intravenous methylprednisolone at 8 am, and the same dose at 4 pm. Methylprednisolone clearance was 28% greater ...
Abstract. Objective: To characterize and compare the pharmacokinetics of a single intravenous dose of methylprednisolone in elderly and young healthy males. Design: A randomized, parallel pharmacokinetic trial. Setting: A public university-affiliated hospital.
11 Απρ 2013 · Several recent studies have reported the benefits of intravenous bolus injection of methylprednisolone (MP) for episodic CH. In this case series, we evaluated the efficacy of this treatment for Japanese male patients experiencing frequent CH attacks.
18 Δεκ 2021 · All the patients started receiving off-label treatment with IV methylprednisolone pulse 500 mg/day for 3 days, followed by oral methylprednisolone 1 mg/kg once daily, then tapered by 10−20 mg/day and finishing with 10mg. Methylprednisolone was given as single dose in the morning.
