Αποτελέσματα Αναζήτησης
11 Ιαν 2024 · Gene vaccines work by harnessing advances in biochemistry, molecular biology, genetics and chemistry to deliver selected portions of the deoxyribonucleic acid (DNA), or messenger ribonucleic acid (mRNA), of the pathogen of interest.
4 Οκτ 2024 · A deeper understanding of the mechanisms of action of mRNA vaccines, application of novel technologies enabling rational antigen design, and innovative vaccine delivery strategies and...
23 Δεκ 2020 · RNA vaccines encode the antigen of interest in messenger RNA (mRNA) or self-amplifying RNA (saRNA) – molecular templates used by cellular factories to produce proteins. Because of its transitory nature, there is zero risk of it integrating with our own genetic material.
25 Αυγ 2021 · Clinically used synthetic mRNA is transcribed in vitro from a DNA plasmid by using the bacteriophage RNA polymerase T7 (T3 and SP6 polymerases can also be used).
DNA and messenger RNA (mRNA) vaccines do not require the use of a live infectious agent such as a bacteria or virus, have been shown to stimulate disease-fighting responses in T-cells and B-cells, and are more stable, less costly and easier to produce in mass quantities than traditional vaccines.
1 Ιουλ 2024 · Nucleic acid technology has revolutionized vaccine development, enabling rapid design and production of RNA and DNA vaccines for prevention and treatment of diseases. The successful deployment of mRNA and plasmid DNA vaccines against COVID-19 has further validated the technology.
Co-delivery of multiple mRNAs enables synergistic effects and further enhances immunity in some cases. In this chapter, we overview the recent progress and existing challenges in the formulation and delivery technologies of mRNA vaccines with perspectives for future development. 1. Introduction.
