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Recent successful anti-inflammatory therapies targeting TNFα seem to be attributed to disrupting the inflammatory Loop 1. These findings suggest that a therapeutic approach targeting the ROS-TNFα amplification loop would significantly reduce inflammation-mediated damage in the joints of RA patients.
- Dietary antioxidants in inflammatory arthritis: do they have any role ...
The role of dietary antioxidants in the prevention and...
- Efficacy of N-Acetylcysteine as an Adjuvant Therapy for Rheumatoid ...
Aims/Background Rheumatoid arthritis (RA) is an inflammatory...
- Dietary antioxidants in inflammatory arthritis: do they have any role ...
The role of dietary antioxidants in the prevention and amelioration of symptoms in inflammatory joint disease has been of interest for many years. Epidemiological studies provide evidence of a link between dietary antioxidant intake and the likelihood of developing inflammatory arthritis.
The therapeutic goal is to control the systemic inflammation to obtain not only the remission of symptoms, but also improve general state of health. Although recent biologic immunosuppressive therapies targeting pro-inflammatory cytokines have spawned a paradigm shift regarding the prognosis of RA, these therapies possess inherent side effects.
3 ημέρες πριν · Aims/Background Rheumatoid arthritis (RA) is an inflammatory autoimmune disease and N-acetylcysteine (NAC) is considered a potential therapeutic agent for RA due to strong antioxidant and anti-inflammatory properties. Therefore, this systematic review and meta-analysis aimed to evaluate the efficacy of NAC as an adjuvant therapy for RA. Methods A systematic search was conducted across five ...
In the past 30 years, several clinical studies evaluated the potential of antioxidant therapies for RA using predominantly synthetic forms of SOD or the ROS scavenger edaravone [76-79]. However,...
1 Σεπ 2020 · Polyphenolic compounds suppress oxidative stress and inflammation in OA joints. Polyphenols inhibit the activation of key signaling pathways in OA pathogenesis. We discuss here the possibility of development of polyphenol (s) for OA management.
23 Μαΐ 2007 · Antioxidant supplements and diets have long been advocated for the treatment of rheumatoid arthritis (RA), osteoarthritis (OA) and other inflammatory arthritis.
