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The speckled pattern, one of several distinct patterns identified in ANA testing, is associated with antibodies targeting extractable nuclear antigens (ENAs), such as Sm, RNP, SS-A, and SS-B.
17 Ιαν 2019 · Scleroderma or systemic sclerosis: ANA pattern is most commonly speckled, followed by centromeric and less commonly nucleolar. Mixed connective tissue disease: ANA pattern is almost always ...
5 Ιαν 2022 · Second, the nuclear dense fine-speckled (AC-2) and Topo I-like (AC-29) patterns are realigned closer to the nuclear homogeneous pattern (AC-1) to highlight their similarities in staining of both interphase nuclei and mitotic condensed chromatin.
21 Φεβ 2024 · ANA patterns can be associated with different autoimmune conditions. These patterns can range from homogenous to speckled, and each carries its own significance in terms of potential autoimmune conditions. Below is a summary of the patterns discussed: Homogenous pattern: Also called nuclear homogenous.
23 Νοε 2020 · The highest scores for clinical relevance were obtained for the centromere (AC-3) and homogeneous (AC-1) pattern, followed by the nuclear speckled (AC-2,4,5) and cytoplasmic reticular (AC-21) patterns.
5 Ιαν 2022 · The International Consensus on ANA Patterns (ICAP) classifies 30 relevant patterns (AC-0 to AC-29). AC-4 (fine speckled nuclear pattern) is associated to anti-SS-A/Ro, anti-SS-B/La, and several...
For example, as indicated in the "antigen association section" of ICAP website, the nuclear coarse speckled pattern (AC-5) is associated mainly with anti-Sm and anti-U1-RNP antibodies, whereas the nuclear fine speckled pattern (AC-4) has a broader target antigen association.
