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Cardiopulmonary failure and acute cerebral events have been described as the leading cause of mortality in adult mitochondrial patients. 15 Patients with mitochondrial disease are more likely to have underlying myopathy, immobility, dysphagia, chronic intestinal pseudo-obstruction (CIPO), cardiomyopathy, and cardiac arrhythmias including Wolf ...
- Mitochondrial myopathies diagnosed in adulthood: clinico-genetic ...
We performed a retrospective chart review of adult patients...
- Mitochondrial myopathies diagnosed in adulthood: clinico-genetic ...
12 Ιουν 2024 · Mitochondrial disease results from failure of mitochondria to function properly. This can lead to less energy, cell injury and cell death. The most common organs that may experience damage are the brain, heart, liver, muscles, kidneys and the endocrine system.
This review is aimed at a general medical and neurologist readership and provides a clinical approach to the recognition, investigation, and treatment of mitochondrial myopathies. Emphasis is placed on practical management considerations while including some recent updates in the field.
19 Μαρ 2024 · Although mitochondria are known to play a role in diverse cellular functions including redox balance, apoptosis, fatty acid oxidation, and calcium homeostasis, this review will focus on the treatment of mitochondrial diseases due to pathologic dysfunction of the mitochondrial respiratory chain.
27 Ιουλ 2017 · Hypothalamic growth hormone deficiency and supplementary GH therapy in two patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes.
14 Φεβ 2024 · We performed a retrospective chart review of adult patients diagnosed with mitochondrial myopathy at Mayo Clinic (2005–21). We identified 94 patients. Median time from symptom onset to diagnosis was 11 years (interquartile range 4–21 years). Median age at diagnosis was 48 years (32–63 years).
This review focuses on the pathology, causes, risk factors, symptoms, prevalence data, symptomatic treatments, and new research aimed at possible preventions and/or treatments of mitochondrial diseases.
